Three Simple Spectrometric Determination of Terbinafine Hydrochloride (TRB) in Pure State and Tablets

Three simple and sensitive procedures (methods A, B and C) for the assay of terbinafine hydrochloride in pure form and formulations are described. Methods A and B are based on the selective oxidation of terbinafine hydrochloride with an excess of oxidant (chloramine T) (in method A or potassium perm...

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Bibliographic Details
Published in:Proceedings of the National Academy of Sciences, India, Section A, physical sciences India, Section A, physical sciences, 2012-09, Vol.82 (3), p.221-224
Main Authors: Mrutyunjayarao, R., Naresh, Saranapu, Pendem, Krishna, Rao, Psnh Ramachandra, Sasttry, C. S. P., Viplava Prasad, U.
Format: Article
Language:English
Subjects:
Applied and Technical Physics
Atomic
Molecular
Optical and Plasma Physics
Physics
Physics and Astronomy
Quantum Physics
Research Article
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Summary:Three simple and sensitive procedures (methods A, B and C) for the assay of terbinafine hydrochloride in pure form and formulations are described. Methods A and B are based on the selective oxidation of terbinafine hydrochloride with an excess of oxidant (chloramine T) (in method A or potassium permanganate in method B) in acidic medium. The unreacted oxidant is then estimated calorimetrically by using an oxidisable dye (gallocyanine) in method A (λ max 540 nm) fast green FCF in method B (λ max 620 nm). Method C is based on the formation of coloured radical anion on treating terbinafine hydrochloride with 2,3 dichloro 5,6-dicyno 1,4 benzoquinone (λ max 450 nm). The variable parameters in all these methods have been optimized. The results were statistically validated.
ISSN:0369-8203
2250-1762
DOI:10.1007/s40010-012-0032-x