CEST Imaging

Chemical exchange saturation transfer (CEST) is a technique that allows generating a contrast in magnetic resonance images based on chemical exchange of free water protons and protons of solute molecules. From the many exogenous and endogenous molecules that have been introduced as CEST contrast age...

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Bibliographic Details
Published in:Current radiology reports (Philadelphia, PA ) PA ), 2014-03, Vol.2 (3), Article 38
Main Authors: Schmitt, Benjamin, Brix, Martin, Domayer, Stephan
Format: Article
Language:English
Subjects:
Cartilage Imaging
Cartilage Imaging (S Trattnig
Imaging
Medicine
Medicine & Public Health
Radiology
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Summary:Chemical exchange saturation transfer (CEST) is a technique that allows generating a contrast in magnetic resonance images based on chemical exchange of free water protons and protons of solute molecules. From the many exogenous and endogenous molecules that have been introduced as CEST contrast agents, CEST contrast mediated by glycosaminoglycans (GAG) in cartilage has been suggested to potentially provide novel avenues for non-invasive investigation of cartilage health. Initial applications showed that the gagCEST contrast is sensitive to the GAG content in cartilage and can detect cartilage defects in patients after cartilage repair surgery in the knee joint.
ISSN:2167-4825
2167-4825
DOI:10.1007/s40134-013-0038-4