Mucosal Barrier Defects: What Have We Learned from Atopic Dermatitis, Asthma, and Allergic Rhinitis?

Purpose of the Review This review covers recent findings describing roles for tight junction proteins in the mucosal barrier and their dysfunction in atopic diseases. Recent Findings Mucosal barrier dysfunction is commonly associated with chronic inflammation. Changes in tight junction protein expre...

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Bibliographic Details
Published in:Current otorhinolaryngology reports 2020-03, Vol.8 (1), p.19-23
Main Authors: Smith, Prestina, Koval, Michael, Levy, Joshua M.
Format: Article
Language:English
Subjects:
Medicine
Medicine & Public Health
Otolaryngic Allergy
Otolaryngic Allergy (SK Wise and C Damask
Otorhinolaryngology
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Summary:Purpose of the Review This review covers recent findings describing roles for tight junction proteins in the mucosal barrier and their dysfunction in atopic diseases. Recent Findings Mucosal barrier dysfunction is commonly associated with chronic inflammation. Changes in tight junction protein expression and localization can be indicators of disease progression in allergic rhinitis. In addition, alterations in tight junctions may have a role in the initial onset of asthma. Lastly, polymorphisms in tight junction genes can be early predictors for atopic dermatitis risk and severity. Summary Tight junctions play a vital role in maintenance of the epithelial barrier and are frequently disrupted in chronic inflammatory disease. Future study is warranted to evaluate novel targeted therapeutics that promote barrier function in the treatment of atopic disease.
ISSN:2167-583X
2167-583X
DOI:10.1007/s40136-020-00267-w