Preclinical Foundation for Normothermic Machine Liver Preservation

Liver transplantation is the primary treatment for end-stage liver disease, but demand exceeds supply due to the shortage of available healthy donor grafts. To increase the supply of useable grafts for transplantation, innovative and better preservation methods are needed to enable the use of livers...

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Bibliographic Details
Published in:Current transplantation reports 2015-03, Vol.2 (1), p.68-73
Main Authors: Sexton, Daniel, Medearis, Sarah, Liu, Qiang, Iuppa, Giuseppe, Quintini, Cristiano
Format: Article
Language:English
Subjects:
Immunology
Machine Preservation of the Liver (CM Miller
Medicine
Medicine & Public Health
Section Editor
Surgery
Topical Collection on Machine Preservation of the Liver
Transplant Surgery
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Summary:Liver transplantation is the primary treatment for end-stage liver disease, but demand exceeds supply due to the shortage of available healthy donor grafts. To increase the supply of useable grafts for transplantation, innovative and better preservation methods are needed to enable the use of livers from extended criteria donors. Normothermic machine perfusion (NMP) has been extensively studied in the laboratory and holds great potential for expanding the donor pool. This review summarizes the progress that has been made in NMP over the last two decades, with emphasis on the recent studies preparing the method for clinical trials.
ISSN:2196-3029
2196-3029
DOI:10.1007/s40472-014-0037-2