Composite Vascularized Allograft Machine Preservation: State of the Art

Purpose of Review In this review, we aim to introduce the concept of machine perfusion of vascularized composite allografts (VCAs). We briefly discuss the basic elements of the circuit design, role of the temperature during the perfusion, types of perfusate, and future trends in this field. Recent F...

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Bibliographic Details
Published in:Current transplantation reports 2019-12, Vol.6 (4), p.265-276
Main Authors: Rezaei, Majid, Figueroa, Brian, Orfahli, Lynn M., Ordenana, Carlos, Brunengraber, Henri, Dasarathy, Srinivasan, Rampazzo, Antonio, Bassiri Gharb, Bahar
Format: Article
Language:English
Subjects:
Immunology
Machine Preservation of the Liver (C Miller and C Quintini
Medicine
Medicine & Public Health
Section Editors
Surgery
Topical Collection on Machine Preservation of the Liver
Transplant Surgery
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Summary:Purpose of Review In this review, we aim to introduce the concept of machine perfusion of vascularized composite allografts (VCAs). We briefly discuss the basic elements of the circuit design, role of the temperature during the perfusion, types of perfusate, and future trends in this field. Recent Findings Several large animal models have demonstrated the efficacy of machine perfusion over static cold storage. While the maximum allowable ischemia time in VCA is 4–6 h with cold storage method, promising results have been achieved in extended preservation times up to 24 h in machine perfusion technique. Summary Current evidence shows that machine perfusion of VCA can overcome the limitations of static cold storage technique and not only can be considered as a preservation but also as a diagnostic and therapeutic method for the practice of replantation/transplantation.
ISSN:2196-3029
2196-3029
DOI:10.1007/s40472-019-00263-0