Reduction in insulin sensitivity and inadequate β-cell capacity to counteract the increase in insulin resistance in children with idiopathic growth hormone deficiency during 12 months of growth hormone treatment

• Published in: Journal of endocrinological investigation 2015-03, Vol.38 (3), p.351-359
• Main Authors: Ciresi, A., Amato, M. C., Giordano, C.
• Format: Article
• Language: English
• Subjects: Adolescent; Blood Glucose - metabolism; Child; Child, Preschool; Dwarfism, Pituitary - drug therapy; Dwarfism, Pituitary - metabolism; Endocrinology; Female; Glucose Tolerance Test; Hormone Replacement Therapy; Human Growth Hormone - deficiency; Human Growth Hormone - therapeutic use; Humans; Hypopituitarism - drug therapy; Hypopituitarism - metabolism; Insulin - metabolism; Insulin Resistance - physiology; Insulin-Secreting Cells - metabolism; Male; Medicine; Medicine & Public Health; Metabolic Diseases; Original Article; Treatment Outcome
• ISSN: 1720-8386; 1720-8386
• DOI: 10.1007/s40618-014-0184-4

Purpose To evaluate the performance of various indexes of insulin sensitivity and secretion and to identify the most useful indicator of deterioration of glucose metabolism in a cohort of children with growth hormone (GH) deficiency (GHD) during GH treatment. Methods In 73 GHD children (55 M, 18 F; mean age 10.5 years) at baseline and after 12 months of treatment, we evaluated a number of surrogate indexes of insulin secretion and sensitivity. In a subgroup of 11 children we also performed an euglycemic hyperinsulinemic clamp. Results After 12 months, a significant increase in fasting glucose ( p