Understanding Hematopoietic Stem Cell Dynamics—Insights from Mathematical Modelling

Purpose of review Hematopoietic stem cells (HSCs) drive blood-cell production (hematopoiesis). Out-competition of HSCs by malignant cells occurs in many hematologic malignancies like acute myeloid leukemia (AML). Through mathematical modelling, HSC dynamics and their impact on healthy blood cell for...

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Bibliographic Details
Published in:Current stem cell reports 2023-03, Vol.9 (1), p.9-16
Main Authors: Pedersen, Rasmus K., Andersen, Morten, Stiehl, Thomas, Ottesen, Johnny T.
Format: Article
Language:English
Subjects:
Biomedical and Life Sciences
Biomedical Engineering/Biotechnology
Biomedicine
Cell Biology
Gene Therapy
Immunology
Life Sciences
Review
Stem Cells
Topical Collection on Mathematical Models of Stem Cell Behavior
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Summary:Purpose of review Hematopoietic stem cells (HSCs) drive blood-cell production (hematopoiesis). Out-competition of HSCs by malignant cells occurs in many hematologic malignancies like acute myeloid leukemia (AML). Through mathematical modelling, HSC dynamics and their impact on healthy blood cell formation can be studied, using mathematical analysis and computer simulations. We review important work within this field and discuss mathematical modelling as a tool for attaining biological insight. Recent findings Various mechanism-based models of HSC dynamics have been proposed in recent years. Key properties of such models agree with observations and medical knowledge and suggest relations between stem cell properties, e.g., rates of division and the temporal evolution of the HSC population. This has made it possible to study how HSC properties shape clinically relevant processes, including engraftment following an HSC transplantation and the response to different treatment. Summary Understanding how properties of HSCs affect hematopoiesis is important for efficient treatment of diseases. Mathematical modelling can contribute significantly to these efforts.
ISSN:2198-7866
2198-7866
DOI:10.1007/s40778-023-00224-5