Are Uterine Grade 3 Endometrioid Adenocarcinoma and Carcinosarcoma Really Clinically Similar?

Purpose The aim of this study was to compare the clinical characteristics and outcomes of the cases with uterine high-grade endometrioid adenocarcinoma (HGEAC) and uterine carcinosarcoma (UCS). Methods A total of 141 patients were included in this study. Of them, 61 cases had uterine HGEAC (group 1)...

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Bibliographic Details
Published in:Indian journal of gynecologic oncology 2019-06, Vol.17 (2), Article 48
Main Authors: Kucukgoz Gulec, Umran, Paydas, Semra, Gumurdulu, Derya, Guzel, Ahmet Baris, Kilic Bagir, Emine, Vardar, Mehmet Ali
Format: Article
Language:English
Subjects:
Medicine
Medicine & Public Health
Oncology
Original Article
Surgical Oncology
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Summary:Purpose The aim of this study was to compare the clinical characteristics and outcomes of the cases with uterine high-grade endometrioid adenocarcinoma (HGEAC) and uterine carcinosarcoma (UCS). Methods A total of 141 patients were included in this study. Of them, 61 cases had uterine HGEAC (group 1) and 80 had UCS (group 2). Both groups were compared in terms of clinical and pathological characteristics including age, stage, initial symptom, surgical approach, myometrial invasion, lymphovascular space invasion (LVSI), lymph node invasion, adjuvant therapy, and survival. The Kaplan–Meier and Cox proportional hazards models were used to compare the outcomes and prognostic factors. Results There were no statistically significant differences between the groups with regard to age, nulliparity, menopausal status, and the main initial symptom. Both groups were similar in terms of stage, depth of myometrial invasion, and lymph node metastasis. Lymphadenectomy was performed in 74% and 91% of the cases in group 1 and group 2, respectively ( p  
ISSN:2363-8397
2363-8400
DOI:10.1007/s40944-019-0296-z