Adult Granulosa Cell Tumor of Ovary: Clinical Study of 10 Cases

Purpose To evaluate the clinicopathological entities of adult granulosa cell tumor of ovary. Method A retrospective analysis of ten cases of adult granulosa cell tumor of ovary managed in a tertiary care center (VPS Lakeshore hospital, Kochi) from 2004 to 2018. Results Ten cases were identified to h...

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Bibliographic Details
Published in:Indian journal of gynecologic oncology 2020-03, Vol.18 (1), Article 2
Main Authors: Kayastha, S., Chitrathara, K., Sigdel, B., Sanam, P., Anupama, S., Remi, A., Augustine, T., Peter, B. C.
Format: Article
Language:English
Subjects:
Medicine
Medicine & Public Health
Oncology
Original Article
Surgical Oncology
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Summary:Purpose To evaluate the clinicopathological entities of adult granulosa cell tumor of ovary. Method A retrospective analysis of ten cases of adult granulosa cell tumor of ovary managed in a tertiary care center (VPS Lakeshore hospital, Kochi) from 2004 to 2018. Results Ten cases were identified to have adult granulosa cell tumor (GCT). Mean age was 45.3 years (range 31–63 years). Irregular cycles, palpable mass and pain abdomen were presenting complains. Palpable abdomino-pelvic mass was present in 7 (70%). Only one case had preoperative rise in serum Ca125 level. Serum inhibin analysis was done in postoperative period only, and one case had raised inhibin. Out of ten cases, 6 underwent laparoscopic surgery for adnexal mass and diagnosis of GCT was made in the final histopathology report. Five of them underwent completion surgery later on. Adjuvant chemotherapy was given in three of the cases. Total of 7 cases (70%) had recurrence. Pelvis was common site of recurrence, and mean duration of recurrence was 5.08 years (24–132 months). Mean disease-free period was 3.97 years (6–132 months). There were four mortalities. The longest follow-up duration for single case till the date was 13 years with recurrence in between. Conclusion Granulosa cell tumor of ovary is rare form of ovarian malignancy. Stage is the important prognostic factor. It has good prognosis compared to epithelial ovarian neoplasm. It is difficult to predict preoperatively. Care should be taken to prevent spillage while dealing with adnexal mass which occurs commonly in minimal access surgery and mini-laparotomy.
ISSN:2363-8397
2363-8400
DOI:10.1007/s40944-019-0343-9