Significance of Y Chromosome in a Turner Mosaic Girl with Dysgerminoma: Case Report with Literature Review

Turner mosaic with Y chromosome material has increased risk for germ cell tumor. A high index of suspicion is important while evaluating an adolescent female with dysgerminoma and amenorrhea. Karyotyping plays a major role in girls with suspected gonadal dysgenesis as detection of Y chromosome neces...

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Bibliographic Details
Published in:Indian journal of gynecologic oncology 2021-12, Vol.19 (4), Article 98
Main Authors: Abinaya, R. N., Rema, P., Suchetha, S., Sivaranjith, J., Dinesh, Dhanya
Format: Article
Language:English
Subjects:
Case Report
Medicine
Medicine & Public Health
Oncology
Surgical Oncology
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Summary:Turner mosaic with Y chromosome material has increased risk for germ cell tumor. A high index of suspicion is important while evaluating an adolescent female with dysgerminoma and amenorrhea. Karyotyping plays a major role in girls with suspected gonadal dysgenesis as detection of Y chromosome necessitates a prophylactic gonadectomy. Here, we report a 21-year-old woman with short stature, normal secondary sexual characteristics and primary amenorrhea who had torsion right ovarian cyst at 13 years of age and underwent excision of gangrenous right ovary. HPR was dysgerminoma ovary. Initial karyotyping done was normal but later in view of disease recurrence and amenorrhea with elevated FSH, repeat karyotyping done which revealed Turner mosaic with Y chromosome. She underwent right adnexal mass excision with prophylactic left gonadectomy.
ISSN:2363-8397
2363-8400
DOI:10.1007/s40944-021-00563-3