Enhanced in vivo biocompatibility of magnesia-contained bioactive glasses

Human blood compatibility of previously prepared magnesia-doped bioactive glass samples was evaluated by hemolysis assay. The in vivo evaluation was carried out using a rat model in which a hole was made in the rat femur bone by drilling and the bioactive glass samples were implanted in the cavity....

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Bibliographic Details
Published in:Journal of the Australian Ceramic Society 2019-06, Vol.55 (2), p.337-342
Main Authors: Arepalli, Sampath Kumar, Tripathi, Himanshu, Manna, Partha Pratim, Pankaj, Paliwal, Krishnamurthy, Sairam, Patne, Shashikant C. U., Pyare, Ram, Singh, S. P.
Format: Article
Language:English
Subjects:
Ceramics
Chemistry and Materials Science
Composites
Glass
Inorganic Chemistry
Materials Engineering
Materials Science
Natural Materials
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Summary:Human blood compatibility of previously prepared magnesia-doped bioactive glass samples was evaluated by hemolysis assay. The in vivo evaluation was carried out using a rat model in which a hole was made in the rat femur bone by drilling and the bioactive glass samples were implanted in the cavity. Histological examination had demonstrated the better bone regeneration and blood vessel formation as compared to the reference one. The in vivo complete blood count (CBC) was also analyzed at different time periods. The in vivo results of magnesium-containing bioactive glasses had shown improved bioactivity as well as better biocompatibility.
ISSN:2510-1560
2510-1579
DOI:10.1007/s41779-018-0239-7