In vitro biological properties of hydroxyapatite/polyamide 12 composites for bone regeneration

Calcium phosphate ceramics and polymer composite have been used in medicine to heal bone defects. Although hydroxyapatite (HA) is a biomaterial with good bio-properties, its composites with polymers in various particle sizes need more investigation to discover and control their effects on the manufa...

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Bibliographic Details
Published in:Journal of the Australian Ceramic Society 2023-12, Vol.59 (5), p.1411-1421
Main Authors: Alahnoori, Amirhossein, Foroozmehr, Ehsan, Badrossamay, Mohsen
Format: Article
Language:English
Subjects:
Ceramics
Chemistry and Materials Science
Composites
Glass
Inorganic Chemistry
Materials Engineering
Materials Science
Natural Materials
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Summary:Calcium phosphate ceramics and polymer composite have been used in medicine to heal bone defects. Although hydroxyapatite (HA) is a biomaterial with good bio-properties, its composites with polymers in various particle sizes need more investigation to discover and control their effects on the manufacturing process. HA composites are chemically similar to bone and hard tissues; then, they are used for implants, coatings, and drug delivery. Producing HA in different sizes with low prices and high quantities to fabricate parts is necessary and valuable, which lead to the creation of a composite with particular properties. In this study, HA was extracted from bovine bone as the natural source. The characterization of the materials was carried out by X-ray diffraction (XRD) and Fourier-transform infrared (FT-IR) spectroscopy. HA and polyamide 12 (PA12) composites were produced with different HA sizes and PA12 weight percentages. The bioactivity and biodegradability of the samples were investigated under vitro conditions after 28 days provided by simulated body fluid (SBF) and phosphate-buffered saline (PBS) solutions. Scanning electron microscopy (SEM) was used for the investigation of apatite formation. The obtained results showed that the extracted HA had good properties and the vital elements of the body were in its structure. PA reduced biodegradability, but its rate was smooth over time. After 28 days, the maximum mass loss was 9%, and the minimum was 2%; smaller HA particle sizes have a more degradability rate, and their bioactivity samples’ surfaces were more smooth and uniform.
ISSN:2510-1560
2510-1579
DOI:10.1007/s41779-023-00924-5