Continuous flow as a benign strategy for the synthesis of Thioesters via selective C-N bond cleavage

A metal-free C-N bond cleavage of amide functionality has been reported for the efficient and rapid synthesis of thioester in a simple flow system. The feasibility of this method has been investigated with various aliphatic and aromatic thiols with N -acylamide derivatives to deliver the correspondi...

Full description

Saved in:
Bibliographic Details
Published in:Journal of flow chemistry 2020-09, Vol.10 (3), p.507-515
Main Authors: Kandasamy, Mohanraj, Amalraj, Antolin Jesila Jesu, Perumal, Gopi, Ganesan, Balaji, Senadi, Gopal Chandru, Lin, Wei-Yu
Format: Article
Language:English
Subjects:
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
Green Chemistry
Industrial Chemistry/Chemical Engineering
Inorganic Chemistry
Nanochemistry
Organic Chemistry
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:A metal-free C-N bond cleavage of amide functionality has been reported for the efficient and rapid synthesis of thioester in a simple flow system. The feasibility of this method has been investigated with various aliphatic and aromatic thiols with N -acylamide derivatives to deliver the corresponding thioesters. The fruitful outcome of this process includes good to excellent yields, broad functional group compatibility and can afford the thioesters in just 40 s. Graphical abstract
ISSN:2062-249X
2063-0212
DOI:10.1007/s41981-020-00090-w