Optimization of continuous-flow diphenyldiazomethane synthesis: an integrated undergraduate chemistry experiment

We present a challenging flow-chemistry experiment concerning the synthesis of diphenyldiazomethane using the Omura-Sharma-Swern oxidation, that we have developed and used in our second-year undergraduate lab classes over the past seven years. The experiment integrates a number of different aspects...

Full description

Saved in:
Bibliographic Details
Published in:Journal of flow chemistry 2021-03, Vol.11 (1), p.59-66
Main Authors: van Summeren, Luuk T. C. G., Gerretzen, Jan, Rutjes, Floris P. J. T., Bloemberg, Tom G.
Format: Article
Language:English
Subjects:
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
Green Chemistry
Industrial Chemistry/Chemical Engineering
Inorganic Chemistry
Nanochemistry
Organic Chemistry
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:We present a challenging flow-chemistry experiment concerning the synthesis of diphenyldiazomethane using the Omura-Sharma-Swern oxidation, that we have developed and used in our second-year undergraduate lab classes over the past seven years. The experiment integrates a number of different aspects and concepts of chemistry that are traditionally taught as separate subjects in undergraduate chemical education: organic synthesis, quantitative chemical analysis, design of experiments, optimization, statistical modelling, computer programming and continuous-flow processes.
ISSN:2062-249X
2063-0212
DOI:10.1007/s41981-020-00107-4