Exploring New Derivatives of 5-Hydroxysalicyaldehyde as Promising Antimicrobial Compounds Towards Drug-Resistant Microorganism

• Published in: Chemistry Africa 2024-08, Vol.7 (6), p.3149-3155
• Main Authors: Todarwal, Minakshee Abhijeet, Sancheti, Rakesh S., Shah, Hakikulla H., Patil, Arvind M., Patil, Rahul D., Bendre, Ratanmala S.
• Format: Article
• Language: English
• Subjects: Chemistry; Chemistry and Materials Science; Chemistry/Food Science; Inorganic Chemistry; Organometallic Chemistry; Original Article
• ISSN: 2522-5758; 2522-5766
• DOI: 10.1007/s42250-024-00973-8

Due to the emergence of drug-resistant microorganisms, treating infectious illnesses is a significant challenge in the medical industry. To counter this, researchers are continuously investigating new drugs to combat infectious illnesses. Hence, we explore the production of new SB derivatives (SB 1 –SB 8 ) obtained from the condensation of 5-hydroxysalicyaldehyde with substituted amines. For structural confirmations of procured compounds, Fourier-transform infrared spectroscopy, 1 H and 13 C-Nuclear magnetic resonance, single crystal X-ray diffraction, and electrospray ionisation mass spectrometry spectroscopic methods of analysis were employed. The SCXRD analysis of compound SB 1 has a triclinic lattice with P-1 and Z = 2 space groups. The antimicrobial attributes of synthesized SB derivatives (SB 1 –SB 8 ) were further investigated. In comparison with conventional antibiotic ampicillin (250 and 100 µg/mL), the compound SB 3 demonstrated enhanced effectiveness against S. aureus (100 µg/mL), E. coli (62.5 µg/mL), and S. pyogenes (50 g/mL), as well as euipotency against the P. aeruginosa (100 µg/mL) microorganisms. Among the synthesized compounds, compounds SB 1 and SB 5 to SB 8 showed notably greater potency (100–250 µg/mL) against the fungus C. albicans in comparison to the conventional drug Griseofulvin (500 µg/mL).