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Roux-en-Y Gastric Bypass Can Modulate Methylation Level of Ghrelin Gene: a 6-Month Longitudinal Study
Recent evidence showed that DNA methylation changes can contribute substantially to body weight regulation, as well as modulate expression of appetite and satiety genes, controlling food intake. To investigate if bariatric surgery could change the methylation levels of specific CpG sites in agouti-r...
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| Published in: | SN comprehensive clinical medicine 2022-09, Vol.4 (1), Article 210 |
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| creator | Wolf, Letícia Santana Nicoletti, Carolina Ferreira Noronha, Natália Yumi de Souza Pinhel, Marcela Augusta Welendorf, Caroline Rossi Delfino, Heitor Bernardes Pereira Salgado Junior, Wilson Nonino, Carla Barbosa |
| description | Recent evidence showed that DNA methylation changes can contribute substantially to body weight regulation, as well as modulate expression of appetite and satiety genes, controlling food intake. To investigate if bariatric surgery could change the methylation levels of specific CpG sites in agouti-related peptide (
AGRP
), ghrelin (
GHRL
) and pro-opiomelanocortin (
POMC
) genes and assess potential relationships of these CpGs sites with anthropometrics changes. This prospective study enrolled 24 women (36.9 ± 10.3 years; Body Mass Index — BMI: 43.3 ± 5.7 kg/m
2
) who underwent Roux-en-Y gastric bypass. DNA methylation levels were assessed before and after 6 months of surgery by Infinium Human Methylation 450 K Bead Chip technology. We found an increase in methylation of cg04924511 in the
GHRL
gene (6%,
p
= 0.0025) after bariatric surgery. There was positive correlation between changes in methylation level of cg05382012 in
AGRP
gene and cg04924511 in
GHRL
gene with fat mass loss after surgery (
r
= 0.729;
p
|
| doi_str_mv | 10.1007/s42399-022-01288-w |
| format | article |
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AGRP
), ghrelin (
GHRL
) and pro-opiomelanocortin (
POMC
) genes and assess potential relationships of these CpGs sites with anthropometrics changes. This prospective study enrolled 24 women (36.9 ± 10.3 years; Body Mass Index — BMI: 43.3 ± 5.7 kg/m
2
) who underwent Roux-en-Y gastric bypass. DNA methylation levels were assessed before and after 6 months of surgery by Infinium Human Methylation 450 K Bead Chip technology. We found an increase in methylation of cg04924511 in the
GHRL
gene (6%,
p
= 0.0025) after bariatric surgery. There was positive correlation between changes in methylation level of cg05382012 in
AGRP
gene and cg04924511 in
GHRL
gene with fat mass loss after surgery (
r
= 0.729;
p
< 0.001 and
r
= 0.566;
p
= 0.012, respectively). Roux-en-Y gastric bypass may change methylation levels of
GHRL
gene and also that these modifications are correlated to fat mass loss.</description><identifier>ISSN: 2523-8973</identifier><identifier>EISSN: 2523-8973</identifier><identifier>DOI: 10.1007/s42399-022-01288-w</identifier><language>eng</language><publisher>Cham: Springer International Publishing</publisher><subject>Medicine ; Medicine & Public Health ; Original Paper ; Topical Collection on Medicine</subject><ispartof>SN comprehensive clinical medicine, 2022-09, Vol.4 (1), Article 210</ispartof><rights>The Author(s), under exclusive licence to Springer Nature Switzerland AG 2022. Springer Nature or its licensor holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c136w-50b09e6370341100627bbf031b3c716d3aac216bbfc022e935897b8735cecdc33</citedby><cites>FETCH-LOGICAL-c136w-50b09e6370341100627bbf031b3c716d3aac216bbfc022e935897b8735cecdc33</cites><orcidid>0000-0001-8559-0772</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids></links><search><creatorcontrib>Wolf, Letícia Santana</creatorcontrib><creatorcontrib>Nicoletti, Carolina Ferreira</creatorcontrib><creatorcontrib>Noronha, Natália Yumi</creatorcontrib><creatorcontrib>de Souza Pinhel, Marcela Augusta</creatorcontrib><creatorcontrib>Welendorf, Caroline Rossi</creatorcontrib><creatorcontrib>Delfino, Heitor Bernardes Pereira</creatorcontrib><creatorcontrib>Salgado Junior, Wilson</creatorcontrib><creatorcontrib>Nonino, Carla Barbosa</creatorcontrib><title>Roux-en-Y Gastric Bypass Can Modulate Methylation Level of Ghrelin Gene: a 6-Month Longitudinal Study</title><title>SN comprehensive clinical medicine</title><addtitle>SN Compr. Clin. Med</addtitle><description>Recent evidence showed that DNA methylation changes can contribute substantially to body weight regulation, as well as modulate expression of appetite and satiety genes, controlling food intake. To investigate if bariatric surgery could change the methylation levels of specific CpG sites in agouti-related peptide (
AGRP
), ghrelin (
GHRL
) and pro-opiomelanocortin (
POMC
) genes and assess potential relationships of these CpGs sites with anthropometrics changes. This prospective study enrolled 24 women (36.9 ± 10.3 years; Body Mass Index — BMI: 43.3 ± 5.7 kg/m
2
) who underwent Roux-en-Y gastric bypass. DNA methylation levels were assessed before and after 6 months of surgery by Infinium Human Methylation 450 K Bead Chip technology. We found an increase in methylation of cg04924511 in the
GHRL
gene (6%,
p
= 0.0025) after bariatric surgery. There was positive correlation between changes in methylation level of cg05382012 in
AGRP
gene and cg04924511 in
GHRL
gene with fat mass loss after surgery (
r
= 0.729;
p
< 0.001 and
r
= 0.566;
p
= 0.012, respectively). Roux-en-Y gastric bypass may change methylation levels of
GHRL
gene and also that these modifications are correlated to fat mass loss.</description><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Original Paper</subject><subject>Topical Collection on Medicine</subject><issn>2523-8973</issn><issn>2523-8973</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><recordid>eNp9kM1OwzAQhC0EElXpC3DyCxj8k8QJN6ggIKVC4ufAyXKcTZsq2JWdUPL2GMqBE6cdreZb7QxC54xeMErlZUi4KApCOSeU8Twn-yM04ykXJC-kOP6jT9EihC2llLMkSamcIXhy4ycBS95wqcPgO4Nvpp0OAS-1xSvXjL0eAK9g2ExRdc7iCj6gx67F5cZD31lcgoUrrHFGVs4OG1w5u-6Gsems7vFzFNMZOml1H2DxO-fo9e72ZXlPqsfyYXldEcNEticprWkBmZBUJCxGy7is65YKVgsjWdYIrQ1nWdyZGBYKkcZQdS5FasA0Rog54oe7xrsQPLRq57t37SfFqPruSh26UhFXP12pfYTEAQrRbNfg1daNPv4e_qO-AHLVbGU</recordid><startdate>20220924</startdate><enddate>20220924</enddate><creator>Wolf, Letícia Santana</creator><creator>Nicoletti, Carolina Ferreira</creator><creator>Noronha, Natália Yumi</creator><creator>de Souza Pinhel, Marcela Augusta</creator><creator>Welendorf, Caroline Rossi</creator><creator>Delfino, Heitor Bernardes Pereira</creator><creator>Salgado Junior, Wilson</creator><creator>Nonino, Carla Barbosa</creator><general>Springer International Publishing</general><scope>AAYXX</scope><scope>CITATION</scope><orcidid>https://orcid.org/0000-0001-8559-0772</orcidid></search><sort><creationdate>20220924</creationdate><title>Roux-en-Y Gastric Bypass Can Modulate Methylation Level of Ghrelin Gene: a 6-Month Longitudinal Study</title><author>Wolf, Letícia Santana ; Nicoletti, Carolina Ferreira ; Noronha, Natália Yumi ; de Souza Pinhel, Marcela Augusta ; Welendorf, Caroline Rossi ; Delfino, Heitor Bernardes Pereira ; Salgado Junior, Wilson ; Nonino, Carla Barbosa</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c136w-50b09e6370341100627bbf031b3c716d3aac216bbfc022e935897b8735cecdc33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Original Paper</topic><topic>Topical Collection on Medicine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wolf, Letícia Santana</creatorcontrib><creatorcontrib>Nicoletti, Carolina Ferreira</creatorcontrib><creatorcontrib>Noronha, Natália Yumi</creatorcontrib><creatorcontrib>de Souza Pinhel, Marcela Augusta</creatorcontrib><creatorcontrib>Welendorf, Caroline Rossi</creatorcontrib><creatorcontrib>Delfino, Heitor Bernardes Pereira</creatorcontrib><creatorcontrib>Salgado Junior, Wilson</creatorcontrib><creatorcontrib>Nonino, Carla Barbosa</creatorcontrib><collection>CrossRef</collection><jtitle>SN comprehensive clinical medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wolf, Letícia Santana</au><au>Nicoletti, Carolina Ferreira</au><au>Noronha, Natália Yumi</au><au>de Souza Pinhel, Marcela Augusta</au><au>Welendorf, Caroline Rossi</au><au>Delfino, Heitor Bernardes Pereira</au><au>Salgado Junior, Wilson</au><au>Nonino, Carla Barbosa</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Roux-en-Y Gastric Bypass Can Modulate Methylation Level of Ghrelin Gene: a 6-Month Longitudinal Study</atitle><jtitle>SN comprehensive clinical medicine</jtitle><stitle>SN Compr. Clin. Med</stitle><date>2022-09-24</date><risdate>2022</risdate><volume>4</volume><issue>1</issue><artnum>210</artnum><issn>2523-8973</issn><eissn>2523-8973</eissn><abstract>Recent evidence showed that DNA methylation changes can contribute substantially to body weight regulation, as well as modulate expression of appetite and satiety genes, controlling food intake. To investigate if bariatric surgery could change the methylation levels of specific CpG sites in agouti-related peptide (
AGRP
), ghrelin (
GHRL
) and pro-opiomelanocortin (
POMC
) genes and assess potential relationships of these CpGs sites with anthropometrics changes. This prospective study enrolled 24 women (36.9 ± 10.3 years; Body Mass Index — BMI: 43.3 ± 5.7 kg/m
2
) who underwent Roux-en-Y gastric bypass. DNA methylation levels were assessed before and after 6 months of surgery by Infinium Human Methylation 450 K Bead Chip technology. We found an increase in methylation of cg04924511 in the
GHRL
gene (6%,
p
= 0.0025) after bariatric surgery. There was positive correlation between changes in methylation level of cg05382012 in
AGRP
gene and cg04924511 in
GHRL
gene with fat mass loss after surgery (
r
= 0.729;
p
< 0.001 and
r
= 0.566;
p
= 0.012, respectively). Roux-en-Y gastric bypass may change methylation levels of
GHRL
gene and also that these modifications are correlated to fat mass loss.</abstract><cop>Cham</cop><pub>Springer International Publishing</pub><doi>10.1007/s42399-022-01288-w</doi><orcidid>https://orcid.org/0000-0001-8559-0772</orcidid></addata></record> |
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| language | eng |
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| source | Springer Link; Alma/SFX Local Collection |
| subjects | Medicine Medicine & Public Health Original Paper Topical Collection on Medicine |
| title | Roux-en-Y Gastric Bypass Can Modulate Methylation Level of Ghrelin Gene: a 6-Month Longitudinal Study |
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