Alkaloid-rich extract of Buchholzia coriacea seed mitigate the effect of copper-induced toxicity in Drosophila melanogaster

Buchholzia coriacea is known for its anti-oxidative, anti-inflammatory, and anti-diabetic properties. This study evaluated the effect of alkaloid-rich extract of Buchholzia coriacea seed (ArEBCs) against copper-induced toxicity in Drosophila melanogaster . The flies were exposed to graded doses (25...

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Bibliographic Details
Published in:Vegetos - International journal of plant research 2024-04, Vol.37 (2), p.460-468
Main Authors: Anadozie, Scholastica O., Aduma, Asueiza U., Adewale, Olusola B.
Format: Article
Language:English
Subjects:
Biomedical and Life Sciences
Life Sciences
Plant Anatomy/Development
Plant Breeding/Biotechnology
Plant Physiology
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Summary:Buchholzia coriacea is known for its anti-oxidative, anti-inflammatory, and anti-diabetic properties. This study evaluated the effect of alkaloid-rich extract of Buchholzia coriacea seed (ArEBCs) against copper-induced toxicity in Drosophila melanogaster . The flies were exposed to graded doses (25 to 200 mg/kg diet) of ArEBCs for 12 days and thereafter, a survival test was carried out to determine the safe and therapeutic doses used in the ameliorative study. For this, flies were exposed to CuSO 4 (1 mM) alone or in combination with ArEBCs (25 and 50 mg/kg diet) for 5 days. Locomotor activity and biochemical assays such as glucose (GLU) level, acetylcholinesterase (AChE) activity, malonaldehyde (MDA) and antioxidant biomarkers (catalase and reduced glutathione) were performed to assess the effect of ArEBCs on the copper-induced flies. Copper-exposed flies showed reduced survival rates and disrupted locomotor activity when compared to the control flies. In addition, a significant (p 
ISSN:2229-4473
2229-4473
DOI:10.1007/s42535-023-00760-9