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The Role of Pericytes in the Articular Environment—a Review
Purpose of review Osteoarthritis (OA) is the most common chronic disease involving joints. The limited intrinsic regeneration potential of articular cartilage (AC) tissue poses a big challenge from a therapeutic perspective. Recent findings Treatment options for OA are sparse, and investigators have...
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| Published in: | Current tissue microenvironment reports 2022-09, Vol.3 (4), p.77-82 |
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| Main Authors: | , , , , , , , , |
| Format: | Article |
| Language: | English |
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| cited_by | cdi_FETCH-LOGICAL-c1368-b2b02dc1be23d0a2d4f2f7cc7d951a6483aa06cd1caa922c7e3a8abafec282713 |
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| cites | cdi_FETCH-LOGICAL-c1368-b2b02dc1be23d0a2d4f2f7cc7d951a6483aa06cd1caa922c7e3a8abafec282713 |
| container_end_page | 82 |
| container_issue | 4 |
| container_start_page | 77 |
| container_title | Current tissue microenvironment reports |
| container_volume | 3 |
| creator | Negri, Stefano Li, Zhao Wang, Yiyun Cherief, Masnsen Qin, Qizhi Xu, Jiajia Salazar, Mario Armando Gomez Hsu, Ginny Ching-Yun James, Aaron W. |
| description | Purpose of review
Osteoarthritis (OA) is the most common chronic disease involving joints. The limited intrinsic regeneration potential of articular cartilage (AC) tissue poses a big challenge from a therapeutic perspective.
Recent findings
Treatment options for OA are sparse, and investigators have turned to the use of mesenchymal stem/progenitor cells (MSCs/MPCs) or minimally manipulated tissues containing such stem-like cells for therapeutic purposes. Pericytes are present within the microvasculature and demonstrate features consistent with a cellular forerunner of culture-derived MSCs/MPCs.
Summary
In this review, we provide an overview on the role of pericytes in OA pathophysiology and their potential application as an injectable cell therapy for cartilage injury and repair. |
| doi_str_mv | 10.1007/s43152-022-00041-8 |
| format | article |
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Osteoarthritis (OA) is the most common chronic disease involving joints. The limited intrinsic regeneration potential of articular cartilage (AC) tissue poses a big challenge from a therapeutic perspective.
Recent findings
Treatment options for OA are sparse, and investigators have turned to the use of mesenchymal stem/progenitor cells (MSCs/MPCs) or minimally manipulated tissues containing such stem-like cells for therapeutic purposes. Pericytes are present within the microvasculature and demonstrate features consistent with a cellular forerunner of culture-derived MSCs/MPCs.
Summary
In this review, we provide an overview on the role of pericytes in OA pathophysiology and their potential application as an injectable cell therapy for cartilage injury and repair.</description><identifier>ISSN: 2662-4079</identifier><identifier>EISSN: 2662-4079</identifier><identifier>DOI: 10.1007/s43152-022-00041-8</identifier><language>eng</language><publisher>Cham: Springer International Publishing</publisher><subject>Biomedical and Life Sciences ; Cancer Research ; Cell Biology ; Fibroadipogenic Progenitors (A Dar ; Life Sciences ; Section Editor ; Topical Collection on Fibroadipogenic Progenitors</subject><ispartof>Current tissue microenvironment reports, 2022-09, Vol.3 (4), p.77-82</ispartof><rights>The Author(s), under exclusive licence to Springer Nature Switzerland AG 2022. Springer Nature or its licensor holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c1368-b2b02dc1be23d0a2d4f2f7cc7d951a6483aa06cd1caa922c7e3a8abafec282713</citedby><cites>FETCH-LOGICAL-c1368-b2b02dc1be23d0a2d4f2f7cc7d951a6483aa06cd1caa922c7e3a8abafec282713</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids></links><search><creatorcontrib>Negri, Stefano</creatorcontrib><creatorcontrib>Li, Zhao</creatorcontrib><creatorcontrib>Wang, Yiyun</creatorcontrib><creatorcontrib>Cherief, Masnsen</creatorcontrib><creatorcontrib>Qin, Qizhi</creatorcontrib><creatorcontrib>Xu, Jiajia</creatorcontrib><creatorcontrib>Salazar, Mario Armando Gomez</creatorcontrib><creatorcontrib>Hsu, Ginny Ching-Yun</creatorcontrib><creatorcontrib>James, Aaron W.</creatorcontrib><title>The Role of Pericytes in the Articular Environment—a Review</title><title>Current tissue microenvironment reports</title><addtitle>Curr. Tissue Microenviron. Rep</addtitle><description>Purpose of review
Osteoarthritis (OA) is the most common chronic disease involving joints. The limited intrinsic regeneration potential of articular cartilage (AC) tissue poses a big challenge from a therapeutic perspective.
Recent findings
Treatment options for OA are sparse, and investigators have turned to the use of mesenchymal stem/progenitor cells (MSCs/MPCs) or minimally manipulated tissues containing such stem-like cells for therapeutic purposes. Pericytes are present within the microvasculature and demonstrate features consistent with a cellular forerunner of culture-derived MSCs/MPCs.
Summary
In this review, we provide an overview on the role of pericytes in OA pathophysiology and their potential application as an injectable cell therapy for cartilage injury and repair.</description><subject>Biomedical and Life Sciences</subject><subject>Cancer Research</subject><subject>Cell Biology</subject><subject>Fibroadipogenic Progenitors (A Dar</subject><subject>Life Sciences</subject><subject>Section Editor</subject><subject>Topical Collection on Fibroadipogenic Progenitors</subject><issn>2662-4079</issn><issn>2662-4079</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><recordid>eNp9kEFOwzAQRS0EElXpBVj5AgF7nMTJgkVVFahUCVSVtTVxJuCqTZCdFnXHITghJ8EQFqxYjGak___o6zF2KcWVFEJfh1TJDBIBcYRIZVKcsBHkOSSp0OXpn_ucTULYRBMomRYqG7Gb9QvxVbcl3jX8kbyzx54Cdy3vozD1vbP7LXo-bw_Od-2O2v7z_QP5ig6O3i7YWYPbQJPfPWZPt_P17D5ZPtwtZtNlYqXKi6SCSkBtZUWgaoFQpw002lpdl5nEPDZBFLmtpUUsAawmhQVW2JCFArRUYwbDX-u7EDw15tW7HfqjkcJ8MzADAxMZmB8GpoghNYRCNLfP5M2m2_s29vwv9QWeS1_p</recordid><startdate>20220926</startdate><enddate>20220926</enddate><creator>Negri, Stefano</creator><creator>Li, Zhao</creator><creator>Wang, Yiyun</creator><creator>Cherief, Masnsen</creator><creator>Qin, Qizhi</creator><creator>Xu, Jiajia</creator><creator>Salazar, Mario Armando Gomez</creator><creator>Hsu, Ginny Ching-Yun</creator><creator>James, Aaron W.</creator><general>Springer International Publishing</general><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>20220926</creationdate><title>The Role of Pericytes in the Articular Environment—a Review</title><author>Negri, Stefano ; Li, Zhao ; Wang, Yiyun ; Cherief, Masnsen ; Qin, Qizhi ; Xu, Jiajia ; Salazar, Mario Armando Gomez ; Hsu, Ginny Ching-Yun ; James, Aaron W.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c1368-b2b02dc1be23d0a2d4f2f7cc7d951a6483aa06cd1caa922c7e3a8abafec282713</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Biomedical and Life Sciences</topic><topic>Cancer Research</topic><topic>Cell Biology</topic><topic>Fibroadipogenic Progenitors (A Dar</topic><topic>Life Sciences</topic><topic>Section Editor</topic><topic>Topical Collection on Fibroadipogenic Progenitors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Negri, Stefano</creatorcontrib><creatorcontrib>Li, Zhao</creatorcontrib><creatorcontrib>Wang, Yiyun</creatorcontrib><creatorcontrib>Cherief, Masnsen</creatorcontrib><creatorcontrib>Qin, Qizhi</creatorcontrib><creatorcontrib>Xu, Jiajia</creatorcontrib><creatorcontrib>Salazar, Mario Armando Gomez</creatorcontrib><creatorcontrib>Hsu, Ginny Ching-Yun</creatorcontrib><creatorcontrib>James, Aaron W.</creatorcontrib><collection>CrossRef</collection><jtitle>Current tissue microenvironment reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Negri, Stefano</au><au>Li, Zhao</au><au>Wang, Yiyun</au><au>Cherief, Masnsen</au><au>Qin, Qizhi</au><au>Xu, Jiajia</au><au>Salazar, Mario Armando Gomez</au><au>Hsu, Ginny Ching-Yun</au><au>James, Aaron W.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Role of Pericytes in the Articular Environment—a Review</atitle><jtitle>Current tissue microenvironment reports</jtitle><stitle>Curr. Tissue Microenviron. Rep</stitle><date>2022-09-26</date><risdate>2022</risdate><volume>3</volume><issue>4</issue><spage>77</spage><epage>82</epage><pages>77-82</pages><issn>2662-4079</issn><eissn>2662-4079</eissn><abstract>Purpose of review
Osteoarthritis (OA) is the most common chronic disease involving joints. The limited intrinsic regeneration potential of articular cartilage (AC) tissue poses a big challenge from a therapeutic perspective.
Recent findings
Treatment options for OA are sparse, and investigators have turned to the use of mesenchymal stem/progenitor cells (MSCs/MPCs) or minimally manipulated tissues containing such stem-like cells for therapeutic purposes. Pericytes are present within the microvasculature and demonstrate features consistent with a cellular forerunner of culture-derived MSCs/MPCs.
Summary
In this review, we provide an overview on the role of pericytes in OA pathophysiology and their potential application as an injectable cell therapy for cartilage injury and repair.</abstract><cop>Cham</cop><pub>Springer International Publishing</pub><doi>10.1007/s43152-022-00041-8</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 2662-4079 |
| ispartof | Current tissue microenvironment reports, 2022-09, Vol.3 (4), p.77-82 |
| issn | 2662-4079 2662-4079 |
| language | eng |
| recordid | cdi_crossref_primary_10_1007_s43152_022_00041_8 |
| source | Springer Link |
| subjects | Biomedical and Life Sciences Cancer Research Cell Biology Fibroadipogenic Progenitors (A Dar Life Sciences Section Editor Topical Collection on Fibroadipogenic Progenitors |
| title | The Role of Pericytes in the Articular Environment—a Review |
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