Sulfated Polysaccharide from Digenea simplex Decreases Intestinal Inflammation in Rats

• Published in: Revista brasileira de farmacognosia 2020-06, Vol.30 (3), p.388-396
• Main Authors: Monturil, Hercylianna Pamplonna Helysaromma Rossa, de Brito, Tarcisio Vieira, da Cruz Júnior, José Simião, Júnior, Genilson José Dias, de Aguiar Magalhães, Diva, Sousa, Stefany Guimarães, Batista, Jalles Arruda, Damasceno, Renan Oliveira Silva, Pereira, Juliana Gomes, Mesquita, Jacilane Ximenes, Vasconcelos, Daniel Fernando Pereira, de Oliveira, Jefferson Soares, Bezerra, Roosevelt Delano S., Soares, Pedro Marcos Gomes, Souza, Marcellus Henrique Loiola Ponte, Freitas, Ana Lúcia Ponte, Barbosa, André Luiz dos R.
• Format: Article
• Language: English
• Subjects: Medicine; Original Article; Pharmacy
• ISSN: 1981-528X; 1981-528X
• DOI: 10.1007/s43450-020-00073-x

Sulfated polysaccharides derived from seaweeds have important biological activities. The aim of this work was to demonstrate the anti-inflammatory effect of a sulfated polysaccharide extracted from the seaweed Digenea simplex (Wulfen) C. Agardh 1822 on 2,4,6-trinitrobenzene sulfonic acid–induced colitis in rats. After inducing colitis, rats were euthanized, and the colon was excised to determine macroscopic lesion scores and wet weight and to histologically evaluate and quantify glutathione, malondialdehyde, myeloperoxidase, nitrate/nitrite, and cytokines. The polysaccharide, composed of β- d -galactose and 3,6-α- l -anhydrogalactose residues, reduced wet weight as well as macroscopic and microscopic lesion scores. It also reduced myeloperoxidase activity; reduced proinflammatory cytokines, malondialdehyde, and nitrate/nitrite levels; and preserved glutathione consumption in the colon. According to these results, we can infer that the sulfated polysaccharide derived from D . simplex has an anti-inflammatory effect on induced colitis in vivo . Graphical Abstract