Alkaloids from the Leaves of Annona crassiflora and Their Cytotoxic Activity

Aporphines are a class of alkaloids mostly reported in Magnoliids. The genus Annona , Annonaceae, presents great structural diversity of these compounds. Chemical investigation of leaves from Annona crassiflora Mart. resulted in the identification of an undescribed aporphine alkaloid, which was name...

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Bibliographic Details
Published in:Revista brasileira de farmacognosia 2021-04, Vol.31 (2), p.244-248
Main Authors: Peña-Hidalgo, Miguel, Furtado, Luciana Costa, Costa-Lotufo, Letícia V., Ferreira, Marcelo J. P., Santos, Déborah Y. A. C.
Format: Article
Language:English
Subjects:
Medicine
Pharmacy
Short Communication
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Summary:Aporphines are a class of alkaloids mostly reported in Magnoliids. The genus Annona , Annonaceae, presents great structural diversity of these compounds. Chemical investigation of leaves from Annona crassiflora Mart. resulted in the identification of an undescribed aporphine alkaloid, which was named as crassiflorine, in addition to six known analogues: anonaine, annoretine, xylopine, tetrahydropalmatrubine, litseglutine B, and stephalagine. The structure of crassiflorine was established through 1D and 2D NMR data in combination with HREIMS and IR analyses. The cytotoxic activity for all tested compounds was marginal (IC 50 > 30 μM) against breast carcinoma (MCF-7) and colorectal carcinoma (HCT-116) cell lines. Graphical abstract
ISSN:1981-528X
1981-528X
DOI:10.1007/s43450-021-00147-4