Zingiberene Protects from Isoproterenol-Induced Cardiotoxicity via Attenuation of Hyperlipidemia and Oxidative Stress in Rats

The effect of zingiberene, an active sequiterpene from Zingiber officinale Roscoe, Zingiberaceae, against isoproterenol-induced cardiotoxicity in rats was evaluated. The rats were pre-treated with zingiberene (50 mg/kg bw) for the period of 45 days and isoproterenol (20 mg/kg bw) administered to exp...

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Published in:Revista brasileira de farmacognosia 2022-02, Vol.32 (1), p.74-80
Main Authors: Asokan, Balakrishnan Ramajayam, Jaikumar, Sankarapillai, Sengottuvelu, Singaravel
Format: Article
Language:English
Subjects:
Medicine
Original Article
Pharmacy
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Summary:The effect of zingiberene, an active sequiterpene from Zingiber officinale Roscoe, Zingiberaceae, against isoproterenol-induced cardiotoxicity in rats was evaluated. The rats were pre-treated with zingiberene (50 mg/kg bw) for the period of 45 days and isoproterenol (20 mg/kg bw) administered to experimental rats for two consecutive days to create cardiotoxicity. Then, the effect of zingiberene on cardiac diagnostic markers (lactate dehydrogenase, creatine kinase-MB isoenzyme and cardiac troponin), cardiac lipid profile, heart lipid peroxidation and antioxidant system (catalase, superoxide dismutase, glutathione peroxidase, reduced glutathione and oxidized glutathione) was evaluated. Isoproterenol administration predominantly altered the levels of triglycerides, cholesterol, phospholipids, free fatty acids and cardiac biomarker enzymes and decreased the antioxidant enzyme activity. On the other hand, pre-treatment with zingiberene significantly ( p  
ISSN:1981-528X
1981-528X
DOI:10.1007/s43450-021-00212-y