Catha edulis and Cathinone Effect on Bone Parameters and Adipokines Gene Expression in Obese Male Mice

This study aims to determine the effects of Catha edulis (Vahl) Forssk. ex Endl., Celastraceae, and its bioactive alkaloid, cathinone, on liver histology, gene expression of inflammatory biomarkers in white adipose tissue, hypothalamus, and histomorphological bone parameters. Thirty male mice (C57BL...

Full description

Saved in:
Bibliographic Details
Published in:Revista brasileira de farmacognosia 2023-10, Vol.33 (5), p.1012-1021
Main Authors: Alshagga, Mustafa Ahmed, Mohamed, Zahurin, Mohamed, Norazlina, Seyedan, Atefehalsadat, Pan, Yan, Lim, Sharoen Yu Ming, Alshawsh, Mohammed Abdullah
Format: Article
Language:English
Subjects:
Medicine
Original Article
Pharmacy
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:This study aims to determine the effects of Catha edulis (Vahl) Forssk. ex Endl., Celastraceae, and its bioactive alkaloid, cathinone, on liver histology, gene expression of inflammatory biomarkers in white adipose tissue, hypothalamus, and histomorphological bone parameters. Thirty male mice (C57BL/6J) were fed a high-fat diet for 8 weeks, divided into 5 groups, and treated daily for another 8 weeks high-fat diet + vehicle (control), HFD + 15 mg/kg orlistat, high-fat diet + 200 mg/kg plant extract, high-fat diet + 400 mg/kg plant extract, and high-fat diet + 3.2mg/kg cathinone. Treatments were carried out once daily by gastric gavage. Blood and tissue samples were collected for histological, biochemical, and gene expression analysis. The results showed the plant extract (400 mg/kg) and cathinone (3.2 mg/kg) displayed a marked reduction of liver fatty changes. All treated groups showed higher serum adiponectin levels compared to the control group ( p
ISSN:1981-528X
1981-528X
DOI:10.1007/s43450-023-00428-0