Noninvasive Assessment of Sex Differences in Arterial Load in Healthy Adults

Background Women have higher risk of heart failure than their male counterparts. Although the mechanical inefficiency of myocardium against an excessive afterload is an important reason of heart failure, little attention has been paid to the sex differences in arterial load and its clinical relevanc...

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Bibliographic Details
Published in:Artery research 2022-09, Vol.28 (3), p.105-111
Main Authors: Lu, Jing, Yin, Lixue
Format: Article
Language:English
Subjects:
Medicine
Medicine & Public Health
Research Article
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Summary:Background Women have higher risk of heart failure than their male counterparts. Although the mechanical inefficiency of myocardium against an excessive afterload is an important reason of heart failure, little attention has been paid to the sex differences in arterial load and its clinical relevance. Results The effective arterial elastance index (EaI), total arterial compliance index (TACI), and systemic vascular resistance index (SVRI) were determined using transthoracic echocardiography combined with cuff-measured brachial blood pressure in 460 healthy adults (230 men). The sex differences in these arterial load indexes were analyzed. No statistical difference was found in the age, heart rate, and stroke volume index (all P < 0.05). After adjustment for the cuff-measured blood pressure; the estimated marginal means (95% CIs) of the EaI was higher in women than in men [0.972 (0.952–0.991) vs 0.743 (0.724–0.763) mmHg m 2 /mL, P  
ISSN:1876-4401
1876-4401
DOI:10.1007/s44200-022-00020-2