Use of a three-phase model with hydroxypropyl-βy̧clodextrin for the direct determination of large octanol-water and cyclodextrin-water partition coefficients

A shake-flask method is presented which uses a three-phase model to measure octanol-water and cyclodextrin-water partition coefficients. Equations are derived which account for all equilibria and which relate the cyclodextrin-water partition coefficient to the formation constant for a cyclodextrin-s...

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Bibliographic Details
Published in:Analytica chimica acta 1991-12, Vol.255 (1), p.157-162
Main Authors: Menges, Randy A., Armstrong, Daniel W.
Format: Article
Language:English
Subjects:
Cyclodextrins
Hydroxypropyl-β-cyclodextrin
Liquid chromatography
Partition coefficients
Shake-flask method
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Summary:A shake-flask method is presented which uses a three-phase model to measure octanol-water and cyclodextrin-water partition coefficients. Equations are derived which account for all equilibria and which relate the cyclodextrin-water partition coefficient to the formation constant for a cyclodextrin-solute complex. The partition coefficients of three aromatic solutes were determined and these values compared well with previously published partition coefficients. Solute concentration was determined using liquid chromatography.
ISSN:0003-2670
1873-4324
DOI:10.1016/0003-2670(91)85101-W