Triangle programmed coulometric flow titration with potentiometric and optical detection

The application of a flow-through titration technique, the so-called triangle programmed coulometric titration, is presented for acid-base titrations using potentiometric and photometric detection. A flow-through capillary glass electrode-saturated calomel electrode pair was employed for potentiomet...

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Bibliographic Details
Published in:Analytica chimica acta 1993-02, Vol.273 (1-2), p.521-530
Main Authors: Fehér, Zsófia, Nagy, Géza, Slezsák, István, Tóth, Klára, Pungor, Ernö
Format: Article
Language:English
Subjects:
Analytical chemistry
Chemistry
Coulometry
Electrochemical methods
Exact sciences and technology
Flow system
Nicotinic acid
Pharmaceuticals
Potentiometry
Titrimetry
Triangle programmed coulometric flow titration
UV-Visible spectrophotometry
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Summary:The application of a flow-through titration technique, the so-called triangle programmed coulometric titration, is presented for acid-base titrations using potentiometric and photometric detection. A flow-through capillary glass electrode-saturated calomel electrode pair was employed for potentiometric detection, and an indicator mixture and a light-emitting diode-phototransistor system was used for photometric detection. In photometric detection the precision of the end-point location was enhanced by the addition of a suitable mixture of Methyl Red and m- Cresol Purple acid-base colour indicators. The suitability of the technique was demonstrated for different acid-base titrations. As an example, the determination of the drug content of a nicotinic acid-containing experimental pharmaceutical preparation is described.
ISSN:0003-2670
1873-4324
DOI:10.1016/0003-2670(93)80198-T