Fluoroquinolone distribution in a phospholipid environment studied by spectrofluorimetry

The intrinscic fluorescence of fluoroquinolones was exploited first to discriminate between fluorophore populations after encapsulation in liposomes, and second to observe by epifluorescence their distribution in phospholipid monolayers. The affinity of fluoroquinolones for a hydrophobic environment...

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Bibliographic Details
Published in:Analytica chimica acta 1994-05, Vol.290 (1), p.58-64
Main Authors: Montero, M.T., Hernández-Borrell, J., Nag, K., Keough, K.M.W.
Format: Article
Language:English
Subjects:
Biological and medical sciences
Fluorimetry
Fluoroquinolones
General pharmacology
Liposomes
Medical sciences
Pharmaceutical
Pharmaceutical technology. Pharmaceutical industry
Pharmacology. Drug treatments
Phospholipids
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Summary:The intrinscic fluorescence of fluoroquinolones was exploited first to discriminate between fluorophore populations after encapsulation in liposomes, and second to observe by epifluorescence their distribution in phospholipid monolayers. The affinity of fluoroquinolones for a hydrophobic environment and especially for phospholipids could help in interpreting the mechanism of drug uptake in bacteria. Additionally, this will lead to improve encapsulation efficiencies of these drugs in liposomes.
ISSN:0003-2670
1873-4324
DOI:10.1016/0003-2670(94)80040-5