Fucose and fucosyllactose enhance in-vitro hippocampal long-term potentiation

Bath application of l-fucose and 2́-fucosyllactose (2́F1 increases the potentiation of the population spike amplitude (POP-spike) and the field excitatory postsynaptic potential (fEPSP) after tetanization of the Schaffer collaterals of the rat hippocampus. The ineffective isome...

Full description

Saved in:
Bibliographic Details
Published in:Brain research 1996-07, Vol.725 (2), p.276-280
Main Authors: Matthies, Henry, Staak, Sabine, Krug, Manfred
Format: Article
Language:English
Subjects:
2&#x0301
-Fucosyllactose
Animals
Biological and medical sciences
Central nervous system
Electrophysiology
Evoked Potentials - drug effects
Fucose - pharmacology
Fundamental and applied biological sciences. Psychology
Glycoprotein
Glycoproteins - biosynthesis
Hippocampus
Hippocampus - drug effects
In Vitro Techniques
l-Fucose
Long-Term Potentiation
Male
Nerve Tissue Proteins - biosynthesis
Rats
Rats, Wistar
Tetany - chemically induced
Vertebrates: nervous system and sense organs
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Bath application of l-fucose and 2́-fucosyllactose (2́F1 increases the potentiation of the population spike amplitude (POP-spike) and the field excitatory postsynaptic potential (fEPSP) after tetanization of the Schaffer collaterals of the rat hippocampus. The ineffective isomers d-fucose and 3-fucosyllactose (3-F1) have no such effect. Since not only the maintenance of long-term potentiation LTP is influenced but also its induction is drastically improved, an effect of the sugars via the formation of glycoproteins but also via different actions on induction mechanisms is discussed.
ISSN:0006-8993
1872-6240
DOI:10.1016/0006-8993(96)00406-4