The agitation-step method for KLa measurement

In a previous work [ J. chem. Technol. Biotechnol. 34B, 121 (1984)] a rapid method was proposed for K L a estimation under growth conditions based on first moment analysis. The response curve of dissolved oxygen concentration is obtained by a sudden change in the stirrer speed while the aeration rat...

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Bibliographic Details
Published in:Chemical engineering science 1990, Vol.45 (6), p.1583-1587
Main Author: Mignone, C.F.
Format: Article
Language:English
Subjects:
Biological and medical sciences
Bioreactors
Biotechnology
Fundamental and applied biological sciences. Psychology
Methods. Procedures. Technologies
Various methods and equipments
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Summary:In a previous work [ J. chem. Technol. Biotechnol. 34B, 121 (1984)] a rapid method was proposed for K L a estimation under growth conditions based on first moment analysis. The response curve of dissolved oxygen concentration is obtained by a sudden change in the stirrer speed while the aeration rate is held constant. The influence of the liquid diffusion film and electrode response on K L a estimation were considered but not the gas phase dynamics because it was assumed that the gas phase remained constant. In the present paper, a new model which considers the influence of the gas phase is proposed. The results show that the gas phase dynamics affect the K L a estimation, and its influence is more pronounced for higher values of K L a and for small aeration rates.
ISSN:0009-2509
1873-4405
DOI:10.1016/0009-2509(90)80010-C