CDP-Choline for the treatment of tardive dyskinesia: A small negative series

Based on the cholinergic-deficiency hypothesis of tardive dyskinesia (TD), we administered cytidine diphosphoryl choline (CDP-Choline) (a naturally occurring biochemical intermediary in the synthesis of phosphatidylcholine), 500 mg twice a day orally, to four women and one man with TD for 2 to 8 wee...

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Bibliographic Details
Published in:Comprehensive psychiatry 1989, Vol.30 (1), p.1-4
Main Authors: Gelenberg, Alan J., Wojcik, Joanne, Falk, William E., Bellinghausen, Barbara, Joseph, Anthony B.
Format: Article
Language:English
Subjects:
Adult
Biological and medical sciences
Choline - analogs & derivatives
Clinical Trials as Topic
Cytidine Diphosphate Choline - therapeutic use
Double-Blind Method
Dyskinesia, Drug-Induced - drug therapy
Female
Humans
Male
Medical sciences
Middle Aged
Miscellaneous
Neuropharmacology
Pharmacology. Drug treatments
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Summary:Based on the cholinergic-deficiency hypothesis of tardive dyskinesia (TD), we administered cytidine diphosphoryl choline (CDP-Choline) (a naturally occurring biochemical intermediary in the synthesis of phosphatidylcholine), 500 mg twice a day orally, to four women and one man with TD for 2 to 8 weeks in a double-blind, placebo-controlled crossover trial. Although the small sample size provides only limited power to detect a treatment effect, there was no evidence of efficacy, adverse effects, or changes in psychopathology.
ISSN:0010-440X
1532-8384
DOI:10.1016/0010-440X(89)90111-9