Androgen levels in women using a single implant of nomegestrol acetate

This study was undertaken to evaluate the effects of a single implant containing nomegestrol acetate (Uniplant) on plasma levels of sex hormone-binding globulin (SHBG), testosterone, free testosterone, androstenedione and on blood pressure, body weight and the development of acne vulgaris. Plasma le...

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Bibliographic Details
Published in:Contraception (Stoneham) 1996, Vol.53 (1), p.37-40
Main Authors: Barbosa, Ione, Coutinho, Elsimar, Athayde, Celia, Ladipo, O.A., Olsson, Sven-Eric, Ulmsten, Ulf
Format: Article
Language:English
Subjects:
Acne Vulgaris - chemically induced
Acne Vulgaris - epidemiology
Adult
Androgens - blood
androstenedione
Androstenedione - blood
Biological and medical sciences
Birth control
Blood Pressure - drug effects
Blood Pressure - physiology
Body Weight - drug effects
Body Weight - physiology
Brazil - epidemiology
Drug Implants
Female
free testosterone
Gynecology. Andrology. Obstetrics
Hormonal contraception
Humans
Incidence
Medical sciences
Megestrol
Norpregnadienes - administration & dosage
Norpregnadienes - adverse effects
Norpregnadienes - pharmacology
Progesterone Congeners - administration & dosage
Progesterone Congeners - adverse effects
Progesterone Congeners - pharmacology
Sex Hormone-Binding Globulin - analysis
SHBG
testosterone
Testosterone - blood
Uniplant
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Summary:This study was undertaken to evaluate the effects of a single implant containing nomegestrol acetate (Uniplant) on plasma levels of sex hormone-binding globulin (SHBG), testosterone, free testosterone, androstenedione and on blood pressure, body weight and the development of acne vulgaris. Plasma levels of sex hormone-binding globulin, testosterone, free testosterone and androstenedione were measured. Blood pressure and body weight were determined. The development of acne vulgaris was evaluated. Total testosterone and androstenedione decreased significantly during two years of Uniplant use but all levels were within the normal range. There were no significant differences in sex hormone-binding globulin and free testosterone during 24 months of Uniplant use. All changes observed in this study were within the normal range. SHBG was not affected by Uniplant use. No significant increase in androgen levels and in the development of acne vulgaris was observed in these women using nomegestrol acetate implant during two years. Based on these results, it is possible to conclude that Uniplant had no androgenic effect in women during this study.
ISSN:0010-7824
1879-0518
DOI:10.1016/0010-7824(95)00256-1