Pathobiology of air pollutants

Results of inhalation exposure of guinea pigs to carbon followed by NO 2, or to NO 2 followed by carbon, are presented to exemplify both specific and general problems inherent in using animal systems to determine injurious effects of environmental agents. Inhalation of carbon alone is followed by a...

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Bibliographic Details
Published in:Environmental research 1967-10, Vol.1 (2), p.178-197
Main Author: Boren, Hollis G.
Format: Article
Language:English
Subjects:
Aerosols
Air Pollution
Animals
Carbon - pharmacology
Drug Synergism
Environmental Exposure
Guinea Pigs
Lung - drug effects
Macrophages
Models, Biological
Nitrogen Dioxide - pharmacology
Pulmonary Alveoli - drug effects
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Summary:Results of inhalation exposure of guinea pigs to carbon followed by NO 2, or to NO 2 followed by carbon, are presented to exemplify both specific and general problems inherent in using animal systems to determine injurious effects of environmental agents. Inhalation of carbon alone is followed by a macrophage response. Subsequent exposure to NO 2 results in lung destruction. Inhalation of NO 2 followed by carbon gives a macrophage response of lesser degree. These findings are interpreted to mean that the sequence of exposure may determine a given response. The limitations of this study indicate the necessity of using approaches which control or measure multiple biologic factors operative at different levels of organization of diverse animal systems.
ISSN:0013-9351
1096-0953
DOI:10.1016/0013-9351(67)90012-6