Mutagenic effects of ozone on human cells exposed in vivo and in vitro based on sister chromatid exchange analysis

A sister chromatid exchange (SCE) analysis was performed on circulating lymphocytes collected from young human volunteers exposed to 0.5 ppm ozone for 2 hr, an exposure simulating conditions in severe air pollution episodes. SCE analysis was also performed on diploid human fetal lung cells (WI-38) e...

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Bibliographic Details
Published in:Environmental research 1979-04, Vol.18 (2), p.336-346
Main Authors: Guerrero, R.R., Rounds, D.E., Olson, R.S., Hackney, J.D.
Format: Article
Language:English
Subjects:
Air Pollutants - toxicity
Cell Line
Chromatids - drug effects
Chromatids - ultrastructure
Chromosome Aberrations
Chromosomes - drug effects
Chromosomes - ultrastructure
Dose-Response Relationship, Drug
Fetus
Humans
Lung
Lymphocytes - drug effects
Lymphocytes - ultrastructure
Mutagens - toxicity
Ozone - toxicity
Respiration
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Summary:A sister chromatid exchange (SCE) analysis was performed on circulating lymphocytes collected from young human volunteers exposed to 0.5 ppm ozone for 2 hr, an exposure simulating conditions in severe air pollution episodes. SCE analysis was also performed on diploid human fetal lung cells (WI-38) exposed to 0, 0.25, 0.50, 0.75, and 1.00 ppm ozone for 1 hr in vitro. No increase in SCEs over controls was demonstrated in the lymphocyte chromosomes. However, a clear dose-related increase in SCEs was observed in the WI-38 cells exposed in vitro.
ISSN:0013-9351
1096-0953
DOI:10.1016/0013-9351(79)90110-5