Epidemiology of Thorotrast-induced hepatic angiosarcoma in the United States

An epidemiologic investigation of hepatic angiosarcoma (HAS) in the United States, directed primarily at the years 1964–1974, has identified 26 cases of Thorotrast-induced HAS. This study indicates that the occurrence of Thorotrast-induced HAS was still increasing in the early 1970s and that a large...

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Bibliographic Details
Published in:Environmental research 1979-02, Vol.18 (1), p.65-73
Main Authors: Falk, Henry, Telles, Norman C., Ishak, Kamal G., Thomas, Louis B., Popper, Hans
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Child
Female
Follow-Up Studies
Hemangiosarcoma - chemically induced
Hemangiosarcoma - epidemiology
Humans
Liver Neoplasms - chemically induced
Liver Neoplasms - epidemiology
Male
Medical Records
Middle Aged
Neoplasms, Radiation-Induced - epidemiology
Risk
Sex Factors
Surveys and Questionnaires
Thorium Dioxide - adverse effects
United States
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Summary:An epidemiologic investigation of hepatic angiosarcoma (HAS) in the United States, directed primarily at the years 1964–1974, has identified 26 cases of Thorotrast-induced HAS. This study indicates that the occurrence of Thorotrast-induced HAS was still increasing in the early 1970s and that a larger proportion of the more recent cases had relatively low-dose Thorotrast procedures and a prolonged latent period. A number of cases were identified who had a history of preexisting liver disease, associated vascular malformations, or exposure to arsenic or iron; the possible role of such additional risk factors is uncertain.
ISSN:0013-9351
1096-0953
DOI:10.1016/0013-9351(79)90139-7