Chronic inhalation study of mice subjected to diethylhydroxylamine, nitroethane, and diethylamine hydrogen sulfite

Institute of Cancer Research Swiss strain mice were subjected to the inhalation of 10.3 ± 3.7 ppm diethylhydroxylamine, 10.1 ± 4.1 ppm nitroethane, and the vapor of diethylamine hydrogen sulfite for over 2 years. Histopathologic evaluation of all organs indicated only a few significant findings. The...

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Bibliographic Details
Published in:Environmental research 1982-04, Vol.27 (2), p.277-289
Main Authors: Heicklen, Julian, Lundgard, Richard, Partymiller, Kenneth, Ferguson, Fred, Putman, Cecelia, Sapanski, Walter, Tankard, Joanne, Billups, Leonard
Format: Article
Language:English
Subjects:
Air Pollutants - toxicity
Alkanes - toxicity
Animals
Carcinogens, Environmental
Diethylamines - toxicity
Ethane - analogs & derivatives
Ethane - toxicity
Female
Hydroxylamines - toxicity
Male
Mice
Neoplasms, Experimental - chemically induced
Nitroparaffins - toxicity
Skin Neoplasms - chemically induced
Smog
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Summary:Institute of Cancer Research Swiss strain mice were subjected to the inhalation of 10.3 ± 3.7 ppm diethylhydroxylamine, 10.1 ± 4.1 ppm nitroethane, and the vapor of diethylamine hydrogen sulfite for over 2 years. Histopathologic evaluation of all organs indicated only a few significant findings. The incidence of all tumors, as well as subcutaneous tumors (principally fibrosarcomas), increased in exposed males with marginal statistical significance ( P = 0.12 and 0.048, respectively). The incidence of all tumors in exposed females decreased with marked statistical significance ( P < 0.0005).
ISSN:0013-9351
1096-0953
DOI:10.1016/0013-9351(82)90083-4