Discriminative stimulus properties of morphine mediated by μ1-opioid receptors

The μ-opioid receptor subtypes involved in the discriminative stimulus properties of morphine were investigated in rats that had been trained to discriminate between 3.0 mg/kg morphine and saline. The discriminative stimulus properties of morphine were significantly attenuated by β-funaltrexamine (a...

Full description

Saved in:
Bibliographic Details
Published in:European journal of pharmacology 1995-09, Vol.284 (1), p.195-198
Main Authors: Suzuki, Tsutomu, Mori, Tomohisa, Tsuji, Minoru, Misawa, Miwa, Nagase, Hiroshi
Format: Article
Language:English
Subjects:
Biological and medical sciences
Drug discrimination
Medical sciences
Morphine
Pharmacology. Drug treatments
Respiratory system
μ 1-Opioid receptor
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The μ-opioid receptor subtypes involved in the discriminative stimulus properties of morphine were investigated in rats that had been trained to discriminate between 3.0 mg/kg morphine and saline. The discriminative stimulus properties of morphine were significantly attenuated by β-funaltrexamine (an irreversible μ-opioid receptor antagonist: 10 and 20 mg/kg) and naloxonazine (an irreversible μ 1-opioid receptor antagonist: 20 mg/kg). These results suggest that the discriminative stimulus properties of morphine may be mediated by μ 1-opioid receptors.
ISSN:0014-2999
1879-0712
DOI:10.1016/0014-2999(95)00440-V