Synthesis of biodegradable copoly( l-lactic acid/aromatic hydroxy acids) with relatively low molecular weight

Biodegradable copolyesters having aromatic rings (C 6H 5, CH 2 · C 6H 5) as side-chain residues, e.g. l-lactic acid (LA)/ dl-mandelic acid (MA) and LA/ l-3-phenyllactic acid (PheLA), were synthesized by direct copolycondensation without catalyst at 200°. These copolyesters were characterized with re...

Full description

Saved in:
Bibliographic Details
Published in:European polymer journal 1990, Vol.26 (12), p.1273-1277
Main Authors: Fukuzaki, Hironobu, Yoshida, Masaru, Asano, Masaharu, Kumakura, Minoru, Imasaka, Kazumichi, Nagai, Tsuneji, Mashimo, Tooru, Yuasa, Hisako, Imai, Kyoichi, Yamanaka, Hidetoshi
Format: Article
Language:English
Subjects:
Applied sciences
Chemical reactions and properties
Degradation
Exact sciences and technology
Organic polymers
Physicochemistry of polymers
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Biodegradable copolyesters having aromatic rings (C 6H 5, CH 2 · C 6H 5) as side-chain residues, e.g. l-lactic acid (LA)/ dl-mandelic acid (MA) and LA/ l-3-phenyllactic acid (PheLA), were synthesized by direct copolycondensation without catalyst at 200°. These copolyesters were characterized with respect to composition ( 1H-NMR spectroscopy), molecular weight (gel permeation chromatography), crystallinity (differential scanning calorimetry) and in vivo degradation (animal experiments). The in vivo degradation pattern changed from a typical parabolic-type to an S-type with increasing aromatic hydroxyacid content in the copolyester and molecular weight of the copolyester. In this case, the degree of in vivo degradation of copoly(LA/PheLA) exceeded that of copoly(LA/MA), because of differences related to the side-chains of aromatic hydroxyacyl units in the copolyesters.
ISSN:0014-3057
1873-1945
DOI:10.1016/0014-3057(90)90139-U