Haemoglobin Warwickshire (β5 [A2] Pro → Arg): A possible ‘fine tuning’ of 2,3-DPG affinity by β5 Pro

The blood of a 67-year-old Scotsman who was admitted to hospital with an abdominal carcinoma showed an abnormal red cell lysis in the oxidase channel of the Technicon H6000 analyser. This is seen regularly with Hb C and sometimes with Hb S and on further investigation a new haemoglobin variant - Hb...

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Bibliographic Details
Published in:FEBS letters 1984-10, Vol.176 (2), p.331-333
Main Authors: Wilson, C.I.D., Cave, R.J., Lehmann, H., Close, Madeleine, Imai†, K.
Format: Article
Language:English
Subjects:
Anemias. Hemoglobinopathies
Biological and medical sciences
Diseases of red blood cells
Hematologic and hematopoietic diseases
Human hemoglobin
Human hemoglobin variant
Medical sciences
β-chain 2,3-DPG binding
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Summary:The blood of a 67-year-old Scotsman who was admitted to hospital with an abdominal carcinoma showed an abnormal red cell lysis in the oxidase channel of the Technicon H6000 analyser. This is seen regularly with Hb C and sometimes with Hb S and on further investigation a new haemoglobin variant - Hb Warwickshire — was found. When the family was examined, other examples were revealed. The haematological parameters were normal. Hb Warwickshire is mildly unstable and whilst in the absence of phosphates its oxygen dissociation does not differ from that of Hb A, a small fall of oxygen affinity is noted when phosphates are present.
ISSN:0014-5793
1873-3468
DOI:10.1016/0014-5793(84)81190-4