Effects of t-butyl-4-hydroxyanisole and other phenolic antioxidants on tumoral cells and Trypanosoma parasites

The antioxidant food additives 2(3)- tert-butyl-4-hydroxyanisole (BHA), 2,6-di( tert-butyl)- p-cresol (BHT) and the methyl and propyl esters of gallic acid inhibited Trypanosoma cruzi culture growth and oxygen consumption. The I 50 values for growth and oxygen uptake with BHA were 0.284 and 0.400 an...

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Bibliographic Details
Published in:FEBS letters 1988-07, Vol.234 (2), p.485-488
Main Authors: Ferreira, J., Coloma, L., Fones, E., Letelier, M.E., Repetto, Y., Morello, A., Aldunate, J.
Format: Article
Language:English
Subjects:
Animals
Antineoplastic Agents
Antioxidants - pharmacology
Antioxidants - therapeutic use
Antiprotozoal Agents
Biological and medical sciences
Butylated Hydroxyanisole - pharmacology
Butylated Hydroxyanisole - therapeutic use
Carcinoma, Ehrlich Tumor - drug therapy
Cell Line
Fundamental and applied biological sciences. Psychology
Human protozoal diseases
Infectious diseases
Life cycle. Host-agent relationship. Pathogenesis
Medical sciences
Mice
Neoplasms, Experimental - drug therapy
Oxygen Consumption - drug effects
Parasitic diseases
Phenols - pharmacology
Phenols - therapeutic use
Protozoa
Protozoal diseases
Respiration inhibition
Species Specificity
t-Butyl-4-hydroxyanisole
Tropical medicine
Trypanosoma brucei brucei - drug effects
Trypanosoma brucei brucei - metabolism
Trypanosoma cruzi - drug effects
Trypanosoma cruzi - metabolism
Trypanosoma cruzi, Trypanosoma brucei, Tumor cell
Trypanosomiasis
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Summary:The antioxidant food additives 2(3)- tert-butyl-4-hydroxyanisole (BHA), 2,6-di( tert-butyl)- p-cresol (BHT) and the methyl and propyl esters of gallic acid inhibited Trypanosoma cruzi culture growth and oxygen consumption. The I 50 values for growth and oxygen uptake with BHA were 0.284 and 0.400 and for BHT 0.083 and 0.235 mM, respectively. Moreover, BHA inhibited the respiration of several tumor cells, as well as of the procyclic and bloodstream trypomastigote forms of T. brucei brucei, with I 50 in the range 0.29–0.52 mM. Inhibition of the parasites' oxygen uptake by BHA was not of the pure Michaelis-Menten type, but may be of a mixed form. It is postulated that these compounds are inhibitors because they resemble ubiquinone.
ISSN:0014-5793
1873-3468
DOI:10.1016/0014-5793(88)80143-1