β-Cyclodextrin interacts with the Alzheimer amyloid β-A4 peptide

Electrospray ionisation mass spectrometry has been used to show that the synthetic 40 amino acid β-amyloid peptide (β1-40) interacts with the cyclic oligosaccharide β-cyclodextrin. This interaction, presumably with the hydrophobic aromatic moieties on the peptide, has been shown to diminish substant...

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Bibliographic Details
Published in:FEBS letters 1994-03, Vol.341 (2), p.256-258
Main Authors: Camilleri, Patrick, Haskins, Neville J., Hewlett, David R.
Format: Article
Language:English
Subjects:
A4 peptide
Alzheimer's disease
Amino Acid Sequence
Amyloid
Amyloid beta-Protein Precursor - chemistry
Amyloid beta-Protein Precursor - metabolism
Amyloid beta-Protein Precursor - toxicity
Animals
beta-Cyclodextrins
Cyclodextrins - metabolism
Electrospray ionisation mass spectrometry
Fibrillisation
Mass Spectrometry - methods
Molecular Sequence Data
Nervous System - drug effects
PC12 Cells
Rats
β-Cyclodextrin
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Summary:Electrospray ionisation mass spectrometry has been used to show that the synthetic 40 amino acid β-amyloid peptide (β1-40) interacts with the cyclic oligosaccharide β-cyclodextrin. This interaction, presumably with the hydrophobic aromatic moieties on the peptide, has been shown to diminish substantially the neurotoxic effects of β1-40 in a cell line.
ISSN:0014-5793
1873-3468
DOI:10.1016/0014-5793(94)80467-2