The variation of magnesium requirement for optimal activation of alkaline phosphatase

The amount of magnesium necessary for optimal activation of alkaline phosphatase at different concentrations of glycerophosphate substrate was found to vary.Decreasing the substrate concentration by a factor of 2000, decreased the magnesium requirements for optimal activation by a factor of only 3....

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Bibliographic Details
Published in:Journal of the Franklin Institute 1954, Vol.257 (2), p.143-144
Main Authors: Ross, M.H., Ely, J.O.
Format: Article
Language:English
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Summary:The amount of magnesium necessary for optimal activation of alkaline phosphatase at different concentrations of glycerophosphate substrate was found to vary.Decreasing the substrate concentration by a factor of 2000, decreased the magnesium requirements for optimal activation by a factor of only 3. At very low substrate concentrations, the amount of magnesium greater than the amount necessary for optimal activation, reduced the amount of enzymatic activity.
ISSN:0016-0032
1879-2693
DOI:10.1016/0016-0032(54)90072-1