The effect of ethionine on tumor growth, content and composition of fat of livers and tumor cells, and glycogen content of liver

Ethionine, 0.1 per cent in the diet, inhibited the growth of the Krebs ascites tumor in mice by about 30 per cent. It caused a marked increase in the fat content of the tumor cells and the liver, and altered the composition of the fat. The changes in the composition of the fat were ( a) a decrease i...

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Bibliographic Details
Published in:Journal of the Franklin Institute 1955, Vol.260 (5), p.424-428
Main Authors: Ely, J.O., Batt, William G.
Format: Article
Language:English
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Summary:Ethionine, 0.1 per cent in the diet, inhibited the growth of the Krebs ascites tumor in mice by about 30 per cent. It caused a marked increase in the fat content of the tumor cells and the liver, and altered the composition of the fat. The changes in the composition of the fat were ( a) a decrease in the phospholipin and fatty acid fractions and ( b) an increase in the neutral fat fraction. The glycogen content of the livers was reduced to a negligible amount. The effect of ethionine on the fat content and composition was more marked in females than in males, although tumor growth was inhibited equally.
ISSN:0016-0032
1879-2693
DOI:10.1016/0016-0032(55)90156-3