Radiofluorination with xenon difluoride: A new high yield synthesis of [ 18F]2-fluoro-2-deoxy- d-glucose

The reaction between [ 18F]xenon difluoridem 3,4,6-tri-O-acetyl- d-glucon boron trifluoride in ether gives exclusively [ 18F]3,4,6-tri-O-acetyl-2-fluoro-2-deoxy- d-glucopyranosyl fluoride, which is hydrolysed with 1 N HCl to [ 18F]2-fluoro-2-deoxy- d-glucose. The overall chemical yield is 75%; the r...

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Bibliographic Details
Published in:The International journal of applied radiation and isotopes 1983, Vol.34 (4), p.743-745
Main Authors: Sood, Sudesh, Firnau, Gunter, Garnett, E.S.
Format: Article
Language:English
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Summary:The reaction between [ 18F]xenon difluoridem 3,4,6-tri-O-acetyl- d-glucon boron trifluoride in ether gives exclusively [ 18F]3,4,6-tri-O-acetyl-2-fluoro-2-deoxy- d-glucopyranosyl fluoride, which is hydrolysed with 1 N HCl to [ 18F]2-fluoro-2-deoxy- d-glucose. The overall chemical yield is 75%; the radiochemical yield is 20%. The procedure takes 45 min.
ISSN:0020-708X
DOI:10.1016/0020-708X(83)90254-5