Determination of O-ethyl S-2-diisopropylaminoethyl methylphosphonothioate (VX) by thermospray liquid chromatography—mass spectrometry

The determination of the nerve agent O-ethyl S-2-diisopropylaminoethyl methylphosphonothioate (VX) by thermospray liquid chromatography—mass spectrometry was studied. The solvent system acetonitrile—methanol—0.25 M ammonium acetate was used on a reversed-phase C 18 column. By selected ion monitoring...

Full description

Saved in:
Bibliographic Details
Published in:Journal of Chromatography A 1990-12, Vol.523, p.151-161
Main Authors: Wils, E.R.J., Hulst, A.G.
Format: Article
Language:English
Subjects:
Analytical chemistry
Chemistry
Chromatographic methods and physical methods associated with chromatography
Exact sciences and technology
Other chromatographic methods
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The determination of the nerve agent O-ethyl S-2-diisopropylaminoethyl methylphosphonothioate (VX) by thermospray liquid chromatography—mass spectrometry was studied. The solvent system acetonitrile—methanol—0.25 M ammonium acetate was used on a reversed-phase C 18 column. By selected ion monitoring at the protonated molecular ion of VX ( m/z 268), the predominant peak in its thermospray mass spectrum, an amount of 200 pg could be detected. For the determination of VX in water at levels below 1 ng/ml, preconcentration by C 18 cartridges was investigated. The applicability of the method was demonstrated by the determination of VX in spiked river waters. A concentration of 0.1 ng/ml could be detected starting from a water sample of 50 ml. A second application concerned the analysis of water extracts of spiked soil samples.
ISSN:0021-9673
DOI:10.1016/0021-9673(90)85019-R