Theory of chiral separation in capillary electrophoresis

The resolution of a pair of enantiomers in chiral capillary electrophoresis (CE) is described by the use of a simple model. The model shows the importance of maximising the electrophoretic mobility difference between the two enantiomers, and also the influence of electroosmotic mobility. The theory...

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Bibliographic Details
Published in:Journal of Chromatography A 1993-04, Vol.636 (1), p.57-62
Main Author: Wren, Stephen A.C.
Format: Article
Language:English
Subjects:
Analytical chemistry
Chemistry
Chromatographic methods and physical methods associated with chromatography
Exact sciences and technology
Other chromatographic methods
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Summary:The resolution of a pair of enantiomers in chiral capillary electrophoresis (CE) is described by the use of a simple model. The model shows the importance of maximising the electrophoretic mobility difference between the two enantiomers, and also the influence of electroosmotic mobility. The theory is supported by results obtained with ephedrine, atenolol and practolol.
ISSN:0021-9673
DOI:10.1016/0021-9673(93)80056-E