Gas chromatographic separation of diastereoisomeric and enantiomeric forms of some fluorinated amino acids on glass capillary columns

The monofluorinated analogues of 2-aminocarboxylic acids up to C 7 were efficiently separated into the diastereomers on glass capillary columns coated with achiral phases BP-1, BP-10 and OV-330. In addition, some difluoro and trifluoro analogues were also measured. Chiral resolution was achieved on...

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Bibliographic Details
Published in:Journal of Chromatography A 1993-06, Vol.639 (2), p.273-279
Main Authors: Vlasáková, V., Tolman, V., Živný, K.
Format: Article
Language:English
Subjects:
Analytical chemistry
Chemistry
Chromatographic methods and physical methods associated with chromatography
Exact sciences and technology
Gas chromatographic methods
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Summary:The monofluorinated analogues of 2-aminocarboxylic acids up to C 7 were efficiently separated into the diastereomers on glass capillary columns coated with achiral phases BP-1, BP-10 and OV-330. In addition, some difluoro and trifluoro analogues were also measured. Chiral resolution was achieved on capillary well-coated open tubular fused-silica columns coated with chiral phases XE-60- l-Val- l-(1-phenylethyl)amide, Chirasil- l-Val and Behenoyl- l-Val- tert.-butylamide. The separation factors and the Kovats indices of the fluorinated amino acids were determined and compared. The erythro racemates display a higher degree of resolution than the threo ones. The order of elution was found to be the l- after the d-solute on all l-phases.
ISSN:0021-9673
DOI:10.1016/0021-9673(93)80263-8