Analysis of irritants by capillary column gas chromatography-tandem mass spectrometry

Daughter spectra were obtained for the molecular and principal electron impact fragmentation ions of four irritants, 1-methoxycycloheptatriene, 2-chloroacetophenone, o-chlorobenzylidenemalononitrile and dibenz[ b, f]-1,4-oxazepin, during capillary column GC-MS/MS analysis. The use of standardized co...

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Bibliographic Details
Published in:Journal of Chromatography A 1995-03, Vol.695 (1), p.65-73
Main Authors: D'Agostino, Paul A., Provost, Lionel R.
Format: Article
Language:English
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Summary:Daughter spectra were obtained for the molecular and principal electron impact fragmentation ions of four irritants, 1-methoxycycloheptatriene, 2-chloroacetophenone, o-chlorobenzylidenemalononitrile and dibenz[ b, f]-1,4-oxazepin, during capillary column GC-MS/MS analysis. The use of standardized collisional activated dissociation cell conditions resulted in the acquisition of daughter spectra suitable for identification and data-base generation purposes. Daughter operation detection limits of 100 pg ( S N > 10:1 ), for the highest molecular mass irritant, dibenz[ b, f]-1,4-oxazepin, were obtained. This level of sensitivity was approximately the same as that routinely obtained for chemical warfare agents during capillary column GC-MS analysis under electro impact ionization conditions. The specificity of GC-MS/MS was demonstrated by spiking a complex diesel exhaust extract, with 1-methoxycycloheptatriene.
ISSN:0021-9673
DOI:10.1016/0021-9673(94)01181-D