High-performance liquid chromatographic separation of β-amino alcohols II. Separation of trans-2-(dialkylamino)cyclohexanols on an amylose-based chiral stationary phase

Direct enantiomeric separations of racemic mixtures of trans-2-(dialkylamino)cyclohexanols were achieved with a variety of alcohol-modified pentane mobile phases and a Chiralpak AD chiral stationary phase. The effects of the aliphatic component and the alcohol modifier in the mobile phase were studi...

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Bibliographic Details
Published in:Journal of Chromatography A 1996, Vol.719 (2), p.315-320
Main Authors: Nicholson, L.W., Pfeiffer, C.D., Goralski, C.T., Singaram, B.
Format: Article
Language:English
Subjects:
Enantiomer separation
trans-2-(Dialkylamino)cyclohexanols
β-Amino alcohol
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Summary:Direct enantiomeric separations of racemic mixtures of trans-2-(dialkylamino)cyclohexanols were achieved with a variety of alcohol-modified pentane mobile phases and a Chiralpak AD chiral stationary phase. The effects of the aliphatic component and the alcohol modifier in the mobile phase were studied independently. A variety of alcohol modifiers were investigated that introduced steric factors or affected hydrogen bonding. Ring-size effects of the substituents were noted.
ISSN:0021-9673
DOI:10.1016/0021-9673(95)00736-9