Solubility, inhibited growth and dissolution kinetics of calcium oxalate crystals in solutions, containing α-ketoglutaric acid

The kinetics of dissolution of calcium oxalate (CaOX) calculi in physiological solutions containing α-ketoglutaric acids at different concentrations were studied, using the change in the Archimedean weight of samples immersed in the solution. It was found that α-ketoglutaric acid (a normal physiolog...

Full description

Saved in:
Bibliographic Details
Published in:Journal of crystal growth 1996-03, Vol.160 (1), p.148-153
Main Authors: Atanassova, S., Neykov, K., Gutzow, I.
Format: Article
Language:English
Subjects:
Biological and medical sciences
Cross-disciplinary physics: materials science
rheology
Exact sciences and technology
Growth from solutions
Materials science
Medical sciences
Methods of crystal growth
physics of crystal growth
Nephrology. Urinary tract diseases
Physics
Urinary lithiasis
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The kinetics of dissolution of calcium oxalate (CaOX) calculi in physiological solutions containing α-ketoglutaric acids at different concentrations were studied, using the change in the Archimedean weight of samples immersed in the solution. It was found that α-ketoglutaric acid (a normal physiological constituent of urine) acts at increased concentrations as a dissolving agent with respect to CaOX calculi. Analysis of the experimental results enabled the determination of the increased solubility of calcium oxalate in the presence of α-ketoglutaric acid which can be defined as a new and promising agent for dissolving CaOX calculi in human urine. The inhibiting effect of α-ketoglutaric acid on CaOX precipitation in human urine is also discussed.
ISSN:0022-0248
1873-5002
DOI:10.1016/0022-0248(95)00545-5