The electro-reduction of the anaesthetic gas isoflurane

The popular anaesthetic gas isoflurane is shown to be electrochemically inert over a wide range of electrode materials in both aqueous and non-aqueous solution. However it is shown that the reduction may be brought about by the use of the radical anion of fluroanthene as a mediator. The mechanism of...

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Bibliographic Details
Published in:Journal of electroanalytical chemistry and interfacial electrochemistry 1988-04, Vol.244 (1), p.203-219
Main Authors: Compton, R.G., Northing, R.J., Waller, A.M., Fleet, G.W.J., Son, J.C., Bashyal, B.P.
Format: Article
Language:English
Subjects:
Chemistry
Electrochemistry
Exact sciences and technology
General and physical chemistry
Kinetics and mechanism of reactions
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Summary:The popular anaesthetic gas isoflurane is shown to be electrochemically inert over a wide range of electrode materials in both aqueous and non-aqueous solution. However it is shown that the reduction may be brought about by the use of the radical anion of fluroanthene as a mediator. The mechanism of this process is deduced by means of rotating disc voltammetry and by in situ electrochemical ESR and a rate constant for the reaction is evaluated. The synthesis of the novel polymer poly-(vinylfluoranthene) is described and it is demonstrated that modified electrodes based on this material are effective in the reduction of isoflurane but have only limited lifetimes. The possibility of amperometric electrochemical sensors for isoflurane based on the chemistry described is discussed.
ISSN:0022-0728
DOI:10.1016/0022-0728(88)80105-0