Quantitative determination of erythromycin and its hydrolysis products by cyclic voltammetry at the interface between water and 1,2-dichloroethane

An electrochemical method for quantifying erythromycin (Er) salts and their hydrolysis products is described. Cyclic voltammetry at the water/1,2-dichloroethane interface in a four-electrode system was used. A linear relationship between I p and the erythromycin concentration was obtained up to the...

Full description

Saved in:
Bibliographic Details
Published in:Journal of electroanalytical chemistry (Lausanne, Switzerland) Switzerland), 1993-11, Vol.360 (1), p.211-219
Main Authors: Yudi, L.M., Baruzzi, A.M., Solis, V.
Format: Article
Language:English
Subjects:
Chemistry
Electrochemistry
Exact sciences and technology
General and physical chemistry
Kinetics and mechanism of reactions
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:An electrochemical method for quantifying erythromycin (Er) salts and their hydrolysis products is described. Cyclic voltammetry at the water/1,2-dichloroethane interface in a four-electrode system was used. A linear relationship between I p and the erythromycin concentration was obtained up to the solubility limit of the antibiotic. The various hydrolysis products which can be obtained in acid or basic solutions were characterized by their respective transfer potentials. Similar hydrolysis products were observed for aged solutions of Er lactobionate. It is concluded that the proposed method is suitable for the quantification of Er and for distinguishing it from its hydrolysis products.
ISSN:1572-6657
1873-2569
DOI:10.1016/0022-0728(93)87014-M